基本信息：
姓名： |
賀超 |
出生年月： |
1993-06 |
性别： |
女 |
碩/博導： |
|
民族： |
漢族 |
開設課程： |
|
職稱： |
副研究員 |
研究方向： |
整合大數據開發人工智能算法創制高産抗病小麥新種質 |
近五年，搭建了小麥高效 gRNA 設計工具，首次從單細胞水平解析了小麥根維管細胞發育的分子調控機制，整合遺傳變異和基因表達調控挖掘了影響小麥産量和品質性狀形成的新基因，為小麥重要農藝性狀的基因組設計育種提供了靶标。目前主要研究方向為整合大數據開發人工智能算法創制高産抗病小麥新種質。
聯系方式：hechao@mail.hzau.edu.cn
科研項目：
1）2023.12-2024.6，新型引導編輯技術開發與應用，科技創新 2030 重大項目子任務，首年經費20萬，排名第1.
發表的論文：
1. He C#, Bi S#, L Y#, S C, Li, Q, Saeed S, Chen W, Zhao C, Xu X, Lan C, Su H, Mao H*, Yan W*. Dynamic atlas of histone modifications and gene regulatory networks in endosperm of bread wheat. Nature Communications. 2024, 15, 9572.
2. Cao S#, Zhao X#, Li Z#*, Yu R, Li Y, Zhou X, Yan W*, Chen D*, He C*. Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification. Plant Diversity. 2024, 46(3):372-385.
3. Ai G#, He C#, Bi S, Zhou Z, Liu A, Hu X, Liu Y, Jin L, Zhou J, Zhang H, Du D, Chen H, Gong X, Saeed S, Su H, Lan C, Chen W, Li Q, Mao H, Li L, Liu H, Chen D, Kaufmann K, Alazab KF, Yan W*. Dissecting the molecular basis of spike traits by integrating gene regulatory network and genetic variation in wheat. Plant Communications. 2024, 14:100879.
4. Zhang L#, He C#, Lai Y#, Wang Y, Kang L, Liu A, Gao Y, Li Z, Yang F, Li Q, Mao H, Chen D, Kaufmann K, Yan W*. Asymmetric gene expression and cell type specific regulatory networks in wheat root revealed by single cell multiomics analysis. Genome Biology. 2023, 24:65.
5. Wang X#, Chen C#, He C*, Chen D and Yan W*. Mapping open chromatin by ATAC-seq in bread wheat. Frontiers in Plant Science. 2022, 13:1074873-1074873.
6. He C#, Liu H#, Chen D, Xie WZ, Wang M, Li Y, Gong X, Yan W*, Chen LL*. CRISPR-Cereal: a guide RNA design tool integrating regulome and genomic variation for wheat, maize and rice. Plant Biotechnology Journal. 2021, 19(11):2141-2143.
7. He C#, Zhang HY#, Zhang YX, Fu P, You LL, Xiao WB, Wang ZH, Song HY, Huang YJ*, Liao JL*. Cytosine methylations in the promoter regions of genes involved in the cellular oxidation equilibrium pathways affect rice heat tolerance. BMC Genomics. 2020, 21(1):560.
8. He C, Xiao X, Zhang Z, Peng Q, Huang Y, Liao JL*. Full-length cDNA library construction and analysis of rice panicle at early milky stage under high temperature stress. Journal of Nuclear Agricultural Sciences, 2015, 29(8):1437-1443.
9. Liu Y#, Xu X#, He C#, Jin L, Zhou Z, Gao J, Wang X, Chen C, Ayaad, Li X & Yan W*. Chromatin loops gather targets of upstream regulators together for efficient gene transcription regulation during vernalization in wheat. Genome Biology (Accept).
