教育背景

1997年畢業于77779193永利官网，獲植物保護學士學位。
1999年考入浙江大學攻讀碩士學位，2004年畢業于浙江大學。

工作經曆

09/2012-現在，77779193永利官网植物科技學院藥用植物研究所教授、藥用植物教研室主任。
12/2009-08/2012, 研究助理, 康乃爾大學，生物醫學工程系（Research Associate, Biomedical Engineering Department, Cornell University）
11/2006-11/2009, 博士後，康乃爾大學，生物醫學工程系（Postdoctoral Associate，Biomedical Engineering Department, Cornell University）
07/2004-10/2006, 助理研究員，中國科學院微生物研究所

研究興趣

炎症（Inflammation）是我們研究的出發點。在現代醫學與免疫學，炎症是機體抵禦外來入侵物以及自身功能紊亂的一種糾錯與調節機制。但是炎症反應中産生的活性氧等物質，也對正常細胞與功能有一定的副作用。大量研究表明，長期炎症可能會誘發癌症、關節炎、糖尿病、肥胖病、心血管病等一些列疾病；上述各類疾病中也伴随高水平的炎症反應。我們注意到中醫有關上火的理論與西醫炎症極其類似，都是描述機體的亞健康狀态。因此，我們将炎症與上火對應，借助現代醫學技術研究上火、去火中藥。大量中藥有上火或去火的功效，但是他們之間平行比較通常是模糊的。我們借助現代免疫學有關炎症的基本概念，利用炎症關系密切的幾個蛋白，在分子水平定量分析中藥材或者天然産物的去火能力，建立了不同藥材之間定性、定量比較分析平台。利用該技術，在化學、藥理學的基礎上我們目前主要關注：1）天然産物抗肥胖病、糖尿病、心血管病藥物的改造與評價；2）以抗炎為導向的中藥輔助抗癌藥物篩選；3）新一代涼茶的創制。目前已經有新型抗肥胖病與糖尿病藥物前體，效果良好；中藥輔助抗癌也将進入臨床觀察研究。我們歡迎有志于藥物開發，對天然藥物化學（有機化學）以及動物藥理學有強烈興趣的同學加入我們實驗室。

藥用真菌靈芝、茯苓、牛樟芝等也是我們的研究興趣之一。我們努力的方向是利用工業化發酵培養，生産和自然狀态下生長的藥材同樣的活性化合物，我們采用獨特的光溫處理方式有些已經超過了自然狀态下生長的含量，一方面減少了對砍伐林木的需求，另一方面成本也降低了很多。

在“一帶一路”國家倡議的大環境下，我們與伊朗、埃及、孟加拉等諸多“一帶一路”沿線國家的專家就傳統藥物領域進行了廣泛的交流與合作。我們目前正在努力向外推廣我國的優秀中藥産品，同時也積極和外放合作引進外域傳統藥材。

胡學博，王嘉男，田倩川。一種利用人微血管内表皮細胞檢測涼茶抗炎活性的方法。申請号，201610819586.2；

胡學博，王嘉男。一種利用人微血管内表皮細胞ICAM-1蛋白表達量檢測涼茶抗炎活性的方法。申請号，20161081953662；

胡學博，張啟雲。一種雙通道蛋白表達的工程酵母的構建方法。申請号，2016101903665；

胡學博，張啟雲。基于ICAM-1信号通路的高通量藥物篩選模型的建立方法。申請号，20161009718882；

胡學博，胡延如。一種提高靈芝菌絲體液體發酵的胞内靈芝三萜含量的方法。申請号，2016100721790；

胡學博，李嘉偉，胡延如。一種基于溫度控制提高靈芝菌絲體液體發酵的胞内靈芝三萜含量的方法。 申請号， 201610784316.3；

胡學博，李嘉偉。一種高胞内靈芝三萜含量的靈芝菌絲體發酵工藝。申請号，2016111805855.5；

胡學博，李嘉偉。一種茯苓菌絲體液體發酵方法。申請号：201710058472.6。

“A Yeast Surface Two-Hybrid System for Quantitative Detection of Protein-Protein Interactions”, Pending. Second petitioner. 美國專利，受理中. 第二申請人。
“The esterase of chrysanthemic acid, its encoding gene, engineered expressing strains and their applications”. Chinese Patent No. CN1766097, 2006. 中國專利，第三申請人。

1. Mohammad Omar Faruque, Gang Feng, Md. Nurul Amin Khan_, James W. Barlow, Umme Ruman Ankhi, Sheng Hu, M. Kamaruzzaman, Shaikh Bokhtear Uddin^#, Xuebo Hu^#. Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh. Journal of Ethonobiology and Ethnomedicine. Accepted. 2019.

2. Jafari M, Akram W, Pang Y, Ahmad A, Ahmed S, Yasin NA, Anjum T, Ali B, Hu X, Li X, Dong S, Cai Q, Ciprian M, Bielec M, Hu S, Sefidkon F, Hu X*.Genetic diversity and biogeography of T. officinale inferred from multi locus sequence typing approach.PLoS One. 2018 Sep 18;13(9):e0203275

3. Zhang Q, Hu S, Wang K, Cui M, Li X, Wang M, Hu X*. Engineering a yeast double-molecule carrier for drug screening. Artif Cells Nanomed Biotechnol. 2018 Apr 3:1-11

4. Faruque MO, Uddin SB, Barlow JW, Hu S, Dong S, Cai Q, Li X, Hu X*.Quantitative Ethnobotany of Medicinal Plants Used by Indigenous Communities in the Bandarban District of Bangladesh.Front Pharmacol. 2018 Feb 6;9:40

5. Zhan C, Ahmed S, Hu S, Dong S, Cai Q, Yang T, Wang X, Li X, Hu X*.Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida.Biochem Biophys Res Commun. 2018 Jan 1;495(1):1271-1277

6. Ahmed S, Liu H, Ahmad A, Akram W, Abdelrahman EKN, Ran F, Ou W, Dong S, Cai Q, Zhang Q, Li X, Hu S, Hu X*. Characterization of Anti-bacterial Compounds from the Seed Coat of Chinese Windmill Palm Tree (Trachycarpus fortunei).Front Microbiol. 2017 Oct 4;8:1894

7. Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X*.Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.Sci Rep. 2017 Apr 19;7:46623

8. Zhan C, Li X, Zhao Z, Yang T, Wang X, Luo B, Zhang Q, Hu Y, Hu X*. Comprehensive Analysis of the Triterpenoid Saponins Biosynthetic Pathway in Anemone flaccida by Transcriptome and Proteome Profiling. Front Plant Sci. 2016, 7:1094

9. Ahmed S, Zhan C, Yang Y, Wang X, Yang T, Zhao Z, Zhang Q, Li X, Hu X*. The Transcript Profile of a Traditional Chinese Medicine, Atractylodes lancea, Revealing Its Sesquiterpenoid Biosynthesis of the Major Active Components. PLoS One. 2016 Mar 18;11(3):e0151975

10. Xin-Mei Zhao, Zhang-Qian Wang, Shao-Hua Shu, Wen-Juan Wang, Hai-Jie Xu, Young-Joon Ahn, Mo Wang*, Xuebo Hu* Ethanol and Methanol Can Improve Huperzine A Production From Endophytic Colletotrichum gloeosporioides ES026. Plos One 2013, 8:e61777.

11. Xuebo Hu, P. Saha, Xiaoyue Chen, Dogeun Kim, Mahesh Devarasetty, Raghavan Varadarajan, Moonsoo Jin. Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions. J. Am. Chem. Soc. 2012, 134:14642-14645.

12. Jacque M Tremblay, Chueh-Ling Kuo, Claudia Abeijon, Jorge Sepulveda, George Oyler, Xuebo Hu, Moonsoo M Jin, Charles B Shoemaker. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon, 2010,56:990-998.

13. Xuebo Hu, Sungkwon Kang, Craig Lefort, Minsoo Kim, Moonsoo Jin. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc. Natl. Acad. Sci. U. S. A. 2010,107: 6252-6257.

14. Xuebo Hu, Sungkwon Kang, Xiaoyue Chen, Shoemaker CB, Moonsoo Jin. Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. J Biol Chem. 2009 12;284(24):16369-76.

15. Xuebo Hu, Huijuan Zhang, Guojun Li, Yuxia Yang, Zhong Zheng, Fengming Song. Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009, 28(6):985-95.

16. Chaozheng Zhang , Yueyong Liu , Liyue Liu , Zhiyong Lou, Hongyan Zhang, Hongqin Miao, Xuebo Hu, Yanping Pang, Bingsheng Qiu. Rice black streaked dwarf virus P9-1, an alpha-helical protein, self-interacts and forms viroplasms in vivo. J Gen Virol. 2008 89:1770-1776.

17. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular characterization and expression analysis of a rice protein phosphatase 2C gene, OsBIPP2C1, and overexpression in transgenic tobacco conferred enhanced disease resistance and abiotic tolerance. Physiol Plant. 2006,127: 225-236.

18. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao, Bingsheng Qiu, Zihe Rao, Po Tien. Structural characterization of Mumps virus fusion protein core. Biochem. Biophys. Res. Commun. 2006, 348:916-922.

19. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular cloning and expression of rice OsTVLP1, encoding a protecin with similarity to TGF-belta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins. DNA Seq. 2006 17(2):152-158.

20. Yong Li, Mingyu Wu, Houhui Song, Xuebo Hu, Bingsheng Qiu. Identification of a tobacco protein interacting with tomato mosaic virus coat protein and facilitating long-distance movement of virus. Arch Virol 2005, 150:1993-2008.

21. Yueyong Liu, Yong Li, Liyue Liu, Xuebo Hu, Bingsheng Qiu. Design of vectors for efficient integration and transformation in Hansenula polymorpha. Biotech Lett. 2005, 27(19):1529-1534.