李國田，男，77779193永利官网教授、博士生導師。長期從事水稻-稻瘟菌互作研究，建立了全基因組測序的水稻快中子突變體庫并綜合多種生物信息學手段對其中突變進行深度分析；并證明利用此突變體庫能夠快速克隆水稻抗病相關基因；闡明了稻瘟菌Mst50蛋白在多個MAPK信号通路中的作用。在Plant Cell、Molecular Plant、Environmental Microbiology、Current Opinion in Microbiology和Rice等學術期刊發表研究論文10餘篇，

本課題組以水稻和稻瘟菌為研究對象，已從水稻突變體庫中篩選出多個抗病突變體，表型突出，正綜合利用生物信息學、遺傳學、基因組學、CRISPR/Cas9等基因編輯以及生化和分子生物學等技術手段深入研究已鑒定的抗病突變體；在稻瘟菌方面，主要從水稻抗病的角度研究此病原真菌的緻病性。本研究室從寄主和病原菌兩方面解析水稻與稻瘟菌互作的分子機制，為稻瘟病的防治提供種質資源和理論基礎

歡迎熱愛生物信息學，水稻以及微生物研究的優秀學生報考本題組研究生！

本課題組計劃招博士後2-3名，請将個人材料發至：li4@mail.hzau.edu.cn ！

教育背景

2002.08-2006.07 西北農林科技大學，生物技術， 學士

2006.08-2008.07 西北農林科技大學，植物病理學， 碩士

2008.09-2013.05 普渡大學（美國），植物病理學， 博士

工作經曆

2013.07-2018.09 勞倫斯伯克利國家實驗室/加州大學戴維斯分校，博士後、助理項目科學家、項目科學家及研究室副主任等職。

(38). Sha G^#, Sun P^#, Kong X, Han X, Sun Q, Fouillen L, Zhao J, Li Y, Yang L, Wang Y, Gong Q, Zhou Y, Zhou W, Jain R, Gao J, Huang R, Chen X, Zheng L, Zhang W, Qin Z, Zhou Q, Zeng Q, Xie K, Xu J, Chiu T, Guo L, Mortimer J, Boutté Y, Li Q, Kang Z, Ronald P.*, Li G*. (2023). Genome editing of a rice CDP-DAG synthase confers multi-pathogen resistance. Nature. doi: 10.1038/s41586-023-06205-2

(37). Zhou Y, Zhao J, Yang L, Bi R, Qin Z, Sun P, Li R, Zhao M, Wang Y, Chen G, Wan H, Zheng L, Wang G, Chen X, Li Q, and Li G*. (2023). Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity. New Phytol.

239:255–270

(36). Yang W, Zhai H, Yang L, Yang Q, Song L, Wu J, Lai Z, and Li G*. (2023). Gap-free nuclear and mitochondrial genomes of Fusarium verticillioides strain HN2. PhytoFrontiers.

doi: 10.1094/PHYTOFR-11-22-0123-A

(35). Zhang W^#, Yang Q^#, Yang L, Li H, Zhou W, Meng J, Hu Y, Wang L, Kang R, Li H, Ding S, Li G*. (2023). High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot. Mol Plant Microbe Interact. doi: 10.1094/MPMI-09-22-0196-A

(34). Wang Y^#, Yang L^#, Yang Q, Dong J, Wang Y, Duan Y, Yin W, Zheng L, Sun W, Fan J, Luo-C, Li G*. (2022) Gap-free nuclear and mitochondrial genomes of Ustilaginoidea virens JS60-2, a fungal pathogen causing rice false smut. Mol Plant Microbe Interact. 35(12):1120-1123

(33). Li R^#, Bi R^#, Cai H, Zhao J, Sun P, Xu W, Zhou Y, Yang W, Zheng L, Chen XL, Wang G, Wang D, Liu J, Teng H, Li G*. (2022) Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase. J Pineal Res. e12839

(32). Yang Q^#, Yang L^#, Wang Y, Chen Y, Hu K, Yang W, Zuo S, Xu J, Kang Z, Xiao X, Li G*. (2022) A high-quality genome of Rhizoctonia solani, a devastating fungal pathogen with a wide host range. Mol Plant Microbe Interact. 35(10):954-958

(31). Chen X, Li X, Duan Y, Pei Z, Liu H, Yin W, Huang J, Luo C, Chen X, Li G, Xie K, Hsiang T, Zheng L. (2022) A secreted fungal subtilase interferes with rice immunity via degradation of SUPPRESSOR OF G2 ALLELE OF skp1. Plant Physiol. 190(2):1474-1489

(30). Chen X, Duan Y, Qiao F, Liu H, Huang J, Luo C, Chen X, Li G, Xie K, Hsiang T, Zheng L. (2022) A secreted fungal effector suppresses rice immunity through host histone hypoacetylation. New Phytol. 235(5):1977-1994

(29). Wang Y^#, Yang L^#, Ma C, Zhou Y, Zhao M, Bi R, Liang X, Peng YL, Yang J, Kang Z, Li G*. (2022) Genome sequence of Magnaporthe oryzae EA18 virulent to multiple widely used rice varieties. Mol Plant Microbe Interact. 35(8):727-730

(28). Li G^#, Wang X, Wang X, Zhang M, Chen XR, Wu J, Gou JY, Ma L. (2022) Editorial: Molecular interactions between crops and phytopathogens, volume II: Rice. Front Plant Sci. 13:984072

(27). Zhang M, Chen XR, Wang X, Li G, Ma L, Gou JY, Wu J, Wang X. (2022) Editorial: Molecular interactions between crops and phytopathogens volume III: Vegetables and other crops. Front Plant Sci. 13:979342

(26). Wang X, Wang X, Chen XR, Wu J, Gou JY, Zhang M, Li G, Ma L. (2022) Editorial: Molecular interactions between crops and phytopathogens, Volume I: Wheat and maize. Front Plant Sci. 13:979855

(25). Cai X, Xiang S, He W, Tang M, Zhang S, Chen D, Zhang X, Liu C, Li G, Xing J, Li Y, Chen XL, Nie Y. (2022) Deubiquitinase Ubp3 regulates ribophagy and deubiquitinates Smo1 for appressorium-mediated infection by Magnaporthe oryzae. Mol Plant Pathol. 23(6):832-844

(24). Zhao J^#, Sun P^#, Sun Q, Li R, Qin Z, Sha G, Zhou Y, Bi R, Zhang H, Zheng L, Chen XL, Yang L, Li Q, Li G*. (2022) The MoPah1 phosphatidate phosphatase is involved in lipid metabolism, development, and pathogenesis in Magnaporthe oryzae Mol Plant Pathol. 23(5):720-732

(23). Yang L, Zhao M, Sha G, Sun Q, Gong Q, Yang Q, Xie K, Yuan M, Mortimer JC, Xie W, Wei T, Kang Z, Li G*. (2022) The genome of the rice variety LTH provides insight into its universal susceptibility mechanism to worldwide rice blast fungal strains. Comput Struct Biotechnol J. 20:1012-1026

(22). Chen X, Li P, Liu H, Chen X, Huang J, Luo C, Li G, Hsiang T, Collinge DB, Zheng L. (2021) A novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungus Ustilaginoidea virens. Virulence 12(1):1563-1579

(21). Jain R, Jenkins J, Shu S, Chern M, Martin JA, Copetti C, Duong PQ, Pham NT, Kudrna DA, Talag J, Schackwitz WS, Lipzen AM, Dilworth D, Bauer D, Grimwood J, Nelson CJ, Xing, Xie W, Barry KW, Wing RA, Schmutz J, Li G*, Ronald PC (2019). Genome sequence of the model rice variety KitaakeX. BMC Genomics 20(1):905(20). Jiang L^#, Li G^#, Chern M, Jain R, Pham NT, Martin JA, Schackwitz WS, Zhao J, Ruan D, Huang R, Zheng J, Ronald PC (2019) Whole-genome sequencing identifies a rice grain shape mutant, gs9-1. Rice (N Y) 12(1):52

(19). Li G, Jones KC, Eudes A, Pidatala VR, Sun J, Xu F, Zhang C, Wei T, Jain R, Birdseye D, Canlas PE, Baidoo EK, Duong PQ, Sharma MK, Singh S, Ruan D, Keasling JD, Mortimer JC, Loqué D, Bartley LE, Scheller HV, Ronald PC (2018) Overexpression of a rice BAHD acyltransferase gene in switchgrass (Panicum virgatum L.) enhances saccharification. BMC Biotechnol 18(1):54

(18). Zhang X, Liu W, Li Y, Li G and Xu JR (2017) Expression of HopAI interferes with MAP kinase signaling in Magnaporthe oryzae. Environ Microbiol. 19(10):4190-4204

(17). Li G, Jain R, Chern M, Pham NT, Martin JA, Wei T, Schackwitz WS, Lipzen AM, Duong PQ, Jones KC, Ruan D, Barry KW, Schmutz J, Ronald PC (2017) The sequences of 1504 rice mutants facilitate rapid functional genomic studies. Plant Cell 29: 1218-1231 (Plant Cell亮點推薦; F1000Prime推薦文章)

(16). Li G, Zhang X, Choi YE, Tao AW, Xu JR (2017) MST50 is involved in multiple MAP kinase signaling pathways in Magnaporthe oryzae. Environ Microbiol. 19(5):1959-1974

(15). Yang J, Hsiang T, Bhadauria V, Chen XL, Li G (2017) Plant fungal pathogenesis. BioMed Res Int. 2017: Article ID 9724283

(14). Zhang X, Jain R, Li G (2016) Roles of Rack1 proteins in fungal pathogenesis. BioMed Res Int. 2016: Article ID 4130376

(13). Li G, Chern M, Jain R, Martin JA, Schackwitz WS, Jiang L, Vega-Sánchez ME, Lipzen AM, Barry KW, Schmutz J, Ronald PC (2016) Genome-wide sequencing of 41 rice (Oryza sativa L.) mutated lines reveals diverse mutations induced by fast-neutron irradiation. Mol Plant. 9: 1078-1081

(12). Wang G, Li G, Zhang S, Jiang C, Qin J, Xu JR (2015) Activation and functional relationship of MoMsb2 with Cbp1 in Magnaporthe oryzae. Environ Microbiol. 17: 2969-81

(11). Yang C, Liu H, Li G, Liu M, Xu JR (2015) The MADS-box transcription FgMcm1 regulates cell identity and fungal development in Fusarium graminearum. Environ Microbiol. 17: 2762-76

(10). Kong LA, Li GT, Liu Y, Liu MG, Zhang SJ, Yang J, Zhou XY, Peng YL, Xu JR (2013) Differences between appressoria formed by germ tubes and appressorium-like structures developed by hyphal tips in Magnaporthe oryzae. Fungal Genet Biol.56:33-41

(9). Li G, Zhou X, Xu JR (2012) Genetic control of infection-related development in Magnaporthe oryzae. Curr Opin Microbiol 15: 678-684

(8). Zhou X, Zhang H, Li G, Shaw B, Xu JR (2012) The Cyclase-associated protein Cap1 is important for proper regulation of infection-related morphogenesis in Magnaporthe oryzae. PLoS Pathog 8: e1002911

(7). Kong LA, Yang J, Li GT, Qi LL, Zhang YJ, Wang CF, Zhao WS, Xu JR, Peng YL (2012) Different chitin synthase genes are required for various developmental and plant infection processes in the rice blast fungus Magnaporthe oryzae. PLoS Pathog 8: e1002526

(6). Wang G, Wang C, Hou R, Zhou X, Li G, Zhang S, Xu JR (2012) The AMT1 arginine methyltransferase gene is important for plant infection and normal hyphal growth in Fusarium graminearum. PLoS One 7: e38324

(5). Li G, Zhou X, Kong L, Wang Y, Zhang H, Zhu H, Mitchell TK, Dean RA, Xu JR (2011) MoSfl1 is important for virulence and heat tolerance in Magnaporthe oryzae. PLoS One 6: e19951

(4). Zhang H, Xue C, Kong L, Li G, Xu JR (2011) A Pmk1-interacting gene is involved in appressorium differentiation and plant infection in Magnaporthe oryzae. Eukaryot Cell 10: 1062-1070

(3). Liu W, Zhou X, Li G, Li L, Kong L, Wang C, Zhang H, Xu JR (2011) Multiple plant surface signals are sensed by different mechanisms in the rice blast fungus for appressorium formation. PLoS Pathog 7: e1001261

(2). Xue XD, Qu ZP, Wang XJ, Zhang YH, Li GT, Huang LL, Kang ZS. Prediction secreted proteins from cDNA library of Puccinia striiformis f. sp. tritici. J. Northwest A&F Univ. (Nat. Sci. Ed.) 37(2):105-111 (in Chinese)

(1). Zhang HY, Li GT, Wang XJ, Duan YH, Xu LS, Guo J, Ma JB, Huang LL, Kang ZS (2009) Cloning and primary characteration analysis of peroxiredoxin gene (TaPrx) from wheat. Sci Agric Sinica 42:1222-1229 (in Chinese)

BOOK CHAPTERS

Zhou X, Li G, Xu JR (2011) Efficient approaches for generating GFP fusion and epitope-tagging constructs in filamentous fungi. Fungal Genomics Methods Mol Biol 722: 199-212