張靜柏，女，1979年生，博士，77779193永利官网教師。1998-2002年就讀于于河北農業大學植物保護專業，2002-2008年就讀于77779193永利官网攻讀植物病理學專業博士學位，2008年1月獲農學博士學位，畢業留校任教，承擔《農業植物病理學》、《農業植物病理學實驗》、《植物病害流行學》、《園林植物病理學》等課程教學。2017年6月-2018年6月在美國麻省大學阿默斯特分校進行訪學研究。從事赤黴菌分子生物學、赤黴菌及其毒素特異抗體分離與毒素分析檢測、小麥抗赤黴菌及毒素分子育種等方面研究，主持相關國家自然基金青年科學基金、教育部高等學校博士學科點專項新教師基金、武漢市科技攻關計劃項目各1項，曾作為主要參與者完成國家“973”、“中德國際合作重點項目”多個國家課題，現作為骨幹力量參加國家重大科技專項-轉基因新品種培育1項、國家重點研發計劃項目1項，共計發表研究論文40餘篇（SCI論文30餘篇），授權或申請專利15項，其中國際專利1項。

1. 橫向項目，湖北省小麥赤黴病菌毒素檢測及新型抗病資源的開發，項目年限：2018-2020，（主持）

2. 科技部，國家重點研發計劃，湖北麥區小麥化肥農藥增效減施技術集成研究與示範，項目年限：2018-2020，（參加）

3. 科技部，國家重大科技專項，抗赤黴病轉基因小麥新品系培育，項目年限：2016-2020，（參加）

4. 農業部，國家科技重大專項轉基因生物新品種培育項目，高抗赤黴病和毒素轉基因小麥新品種培育，項目年限：2014-2016，（參加）

5. 國家自然科學基金青年科學基金項目，赤黴菌緻病相關基因CR1 的鑒定和功能分析，項目年限：2013-2015，（主持）

6. 武漢市科技局，武漢市科技計劃項目，抗伏馬菌素特異重組抗體的分離及應用，項目年限：2013-2014，（主持）

7. 國家自然科學基金面上項目，抗病抗體識别的赤黴病菌表面抗原基因克隆與功能鑒定，項目年限：2013-2016，（參加）

8. 農業部，轉基因重大專項，抗赤黴病轉基因小麥新品系和新種質創制，項目年限：2011-2015，（參加）

9. 教育部，新教師基金，我國長江中下遊小麥、玉米赤黴菌系統群及産毒性比較研究，項目年限：2009-2012，（主持）

部分發明專利：

1. 廖玉才，何偉傑，李和平，易沭遠，張靜柏，黃濤. 鐮刀菌毒素脫毒路徑相關基因ADH、AKR6D1、AKR13B2及其應用. 授權日：2020.08.11

2. Liao, Y.-C., Li, H.-P., Zhang, J.-B., Huang, T., Song, X.-S., Cheng, W., Yang, P. Fusarium chitin synthase gene Chs3b and the use thereof. 授權日：2019.07.16

3. 廖玉才，李和平，張靜柏，楊鵬. 一種禾谷鐮刀菌葡聚糖合成酶基因GLS及應用. 授權日：2019.12.13

4. 廖玉才；宮安東；李和平；張靜柏. 防治作物儲藏期黃曲黴菌及毒素的海藻希瓦氏菌及其應用. 授權日：2018.04.10

5. 廖玉才，宮安東，李和平，張靜柏. 一株防治小麥赤黴病的解澱粉芽孢杆菌及其應用. 授權日：2017.08.15

6. 廖玉才，李和平，胡祖權，張靜柏. 抗伏馬菌素B1的單克隆重組抗體H2.授權日：2015.01.28

7. 廖玉才，李和平，胡祖權，張靜柏. 抗伏馬菌素B1的單克隆重組抗體H7. 授權日：2015.01.28

8. 廖玉才，胡祖權，李和平，張靜柏. 鐮刀菌特異單鍊抗體及制備方法和應用.授權日：2014.09.10

9. 廖玉才，王建華，李和平，張靜柏，黃濤. 一種鐮刀菌單端孢黴烯族A類毒素的分子鑒定方法. 授權日：2014.06.18

10. 廖玉才，王建華，李和平，張靜柏，黃濤，瞿波. 玉米赤黴烯酮毒素的分子檢測方法及應用. 授權日：2014.04.02

主要獎勵：

2014年獲得77779193永利官网教學質量三等獎

學術論文

第一作者或通訊作者文章

1. Yang, P., Yi, S.-Y., Nian, J.-N., Yuan, Q.-S., He, W.-J., Zhang, J.-B*., Liao, Y.-C*. Application of double-strand RNAs targeting chitin synthase, glucan synthase, and protein Kinase reduces Fusarium graminearum spreading in wheat. Frontiers in Microbiology, 2021, 12: 660976.

2. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Zhao, Y., Wu, A.-B., Dong, W.-B., Li, H.-P., Zhang, J.-B*., Liao, Y.-C*. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry, 2020, 321: 126703.

3. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Yuan, Q.-S., Yi, S.-Y., Wu, A.-B., Li H.-P., Gao C.-B., Zhang J.-B*., Liao Y.-C*. Novel soil bacterium strain Desulfitobacterium sp. PGC-3-9 detoxifies trichothecene mycotoxins in wheat via de-epoxidation under aerobic and anaerobic conditions. Toxins, 2020, 12(6): 363.

4. Gong, A.-D., Sun, G.-J., Zhao, Z.-Y., Liao, Y.-C., Zhang, J.-B*. Staphylococcus saprophyticus L-38 produces volatile, 3-dimethyl-1,2-epoxybutane with strong inhibitory activity against Aspergillus flavus germination and aflatoxin production. World Mycotoxin Journal, 2020: 13 (2): 247-258.

5. Hu, Z.-Q., Li, H.-P., Liu, J.-L., Xue, S., Gong, A.-D., Zhang, J.-B*., Liao, Y.-C. Production of a phage-displayed mouse scFv antibody against Fumonisin B1 and molecular docking analysis of their interactions. Biotechnology and Bioprocess Engineering, 2016, 21: 134-143.

6. Wang, J.-H. #, Zhang, J.-B.#, Li, H.-P., Gong, A.-D., Liao, Y.-C. Molecular identification, mycotoxin production and comparative pathogenicity of Fusarium temperatum isolated from maize in China . Journal of Phytopathology, 2014, 162: 147-157.（共同第一作者）

7. Zhang, J.-B., Wang, J.-H., Gong, A.-D., Chen, F.-F., Song, B., Li, H.-P., Li, X., Peng, C.-H., Liao Y.-C*. Natural occurrence of Fusarium head blight, mycotoxins, and mycotoxin-producing strains of Fusarium in commercial fields of wheat in Hubei. Plant Pathology, 2013, 62: 92-102.

8. Li, X.#, Zhang, J.-B.#, Song, B., Li, H.-P., Xu, H. Q., Qu, B., Dang, F.-J., Liao, Y.-C*. Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome P450 gene. Phytopathology, 2010, 100:183-191.

9. Li, H.-P. #, Zhang, J.-B.#, Shi, R.-P., Huang, T., Fischer, R., Liao, Y.-C. Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide. Molecular Plant-Microbe Interaction, 2008, 21:1242-1248.

10. Zhang, J.-B., Li, H.-P., Dang, F.-J., Qu, B., Xu, Y.-B., Zhao, C.-S., Liao, Y.-C. Determination of the trichothecene mycotoxin chemotypes and associated geographical distribution and phylogenetic species of the Fusarium graminearum clade from China. Mycological Research, 2007, 111:967-975.

11. 胡祖權，李和平，劉錦龍，吳平，廖玉才，張靜柏*. 抗伏馬菌素B1單克隆重組抗體的篩選. 基因組學與應用生物學，2015，34(9)：1912-1916

12. 胡祖權，李和平，吳平，廖玉才，張靜柏*. 抗鐮刀菌單鍊抗體在大腸杆菌中可溶性表達條件的研究. 生物技術通報，2015，31(9)：238-243

其他作者英文文章

1. Wang, L., Yan Z., Zhou H.-Y., Fan Y.-Y., Wang C., Zhang, J.-B., Liao, Y.-C., Wu, A.-B. Validation of LC-MS/MS coupled with a chiral column for the determination of 3- or 15-acetyl deoxynivalenol mycotoxins from Fusarium graminearum in wheat. Toxins, 2021, 13(9): 659.

2. Guo, M.-W., Yang, P., Zhang, J.-B., Liu, G., Yuan, Q.-S, He, W.-J., Nian, J.-N., Yi, S.-Y, Huang, T., Liao, Y.-C. Expression of microRNA-like RNA-2 (Fgmil-2) and bioH1 from a single transcript in Fusarium graminearum are inversely correlated to regulate biotin synthesis during vegetative growth and host infection, Molecular Plant Pathology, 2019, 20(11): 1574-1581.

3. Song, X.-S., Xing, S., Li, H.-P., Zhang, J.-B., Qu, B., Jiang, J.-H., Fan, C., Yang, P., Liu, J.-L., Hu, Z.-Q., Xue, S., Liao, Y.-C*. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. New Phytologist, 2016, 210(3): 997-1010.

4. He, W.-J., Yuan, Q.-S, Zhang, Y.-B., Guo, M.-W., Gong, A,-D., Zhang, J.-B., Wu, A.-B., Huang, T., Qu, B., Li, H.-P., Liao, Y.-C. Aerobic de-Epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins, 2016, 8, 277.

5. Cheng, W., Song, X.-S., Li, H.-P., Cao, L.-H., Sun, K., Qiu, X.-L., Xu, Y.-B., Yang, P., Huang, T., Zhang, J.-B., Qu, B., Liao, Y.-C. Host-induced gene silencing of an essential chitin synthase gene confers durable resistance to Fusarium head blight and seedling blight in wheat. Plant Biotechnology Journal, 2015, 13, 1335-1345.

6. Cheng, W., Li, H.-P., Zhang, J.-B., Du, H.-J., Wei, Q.-Y., Huang, T., Yang, P., Kong, X.-W., Liao, Y.-C. Tissue-specific and pathogen-inducible expression of a fusion protein containing a Fusarium-specific antibody and a fungal chitinase protects wheat against Fusarium pathogens and mycotoxins. Plant Biotechnology Journal, 2015, 13: 664-674.

7. Gong, A,-D., Li, H.-P., Shen, L., Zhang, J.-B., Wu, A.-B., He, W.-J., Yuan, Q.-S., He, J.-D., Liao, Y.-C. The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins. Frontiers in Microbiology, 2015, Oct 6. doi: 10.3389/fmicb.2015.01091.

8. Hu, Z.-Q., Li, H.-P., Wu, P., Li, Y.-B., Zhou, Z.-Q., Zhang, J.-B., Liu, J.-L., Liao, Y.-C*. An affinity improved single-chain antibody from phage display of a library derived from monoclonal antibodies detects fumonisins by immunoassay. Analytica Chimica Acta, 2015, 867: 74-82.

9. Gong, A.-D., Li, H.-P., Yuan, Q.-S., Song, X.-S., Yao, W., He, W.-J., Zhang, J.-B., Liao, Y.-C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS ONE, 2015 Feb 17;10(2): e0116871.

10. Song, X.-S., Li, H.-P., Zhang, J.-B., Song, B., Huang, T., Du, X.-M., Gong, A.-D., Liu, Y.-K., Feng, Y.-N., Agboola, R.S., Liao, Y.-C. Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum. Fungal Genetics and Biology, 2014, 63: 24-41.

11. Wang, J.-H., Li, H.-P., Zhang, J.-B., Wang, B.-T., Liao, Y.-C. First report of Fusarium maize ear rot caused by Fusarium kyushuense in China . Plant Disease, 2014, 98: 279-280. DOI: 10.1094/PDIS-05-13-0558-PDN.

12. Xue, S., Li, H.-P., Zhang, J.-B., Liu, J.-L., Hu, Z.-Q., Gong, A.-D., Huang, T., Liao, Y.-C. Chicken single-chain antibody fused to alkaline phosphatase detects Aspergillus pathogens and their presence in natural samples by direct sandwich enzyme-linked immunosorbent assay. Analytical Chemistry, 2013, 85, 10992-10999.

13. Song, B., Li, H.-P., Zhang, J.-B., Wang, J.-H., Gong, A.-D., Song, X.-S., Chen T., Liao, Y.-C. Type II myosin gene in Fusarium graminearum is required for septation, development, mycotoxin biosynthesis and pathogenicity. Fungal Genetics and Biology, 2013, 54: 60-70.

14. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Huang, T., Liu, J.-L., Xue, S., Wu, A.-B., Liao, Y.-C. A phage-displayed chicken single-chain antibody fused to alkaline phosphatase detects Fusarium pathogens and their presence in cereal grains. Analytica Chimica Acta, 2013, 764: 84-92.

15. Gao, C.-S., Kou, X.-J., Li, H.-P., Zhang, J.-B., Saad, A. Sefyan I., Liao, Y.-C. Inverse effects of Arabidopsis NPR1 gene on fusarium seedling blight and fusarium head blight in transgenic wheat. Plant Pathology, 2013, 62: 383-392.

16. Liu, Z.-W., Li, H.-P., Cheng, W., Yang, P., Zhang, J.-B., Gong, A.-D., Feng, Y.-N., Fernando, W. G. D., Liao, Y.-C. Enhanced overall resistance to Fusarium seedling blight and Fusarium head blight in transgenic wheat by co-expression of anti-fungal peptides. European Journal of Plant Pathology, 2012, 134: 721-732.

17. Hu, Z.-Q., Liu, J. L., Li, H.-P., Xing, S., Xue, S., Zhang, J.-B., Wang, J.-H., Nölke, G., Liao, Y.-C. Generation of a highly reactive chicken-derived single-chain variable fragment against Fusarium verticillioides by phage display. International Journal of Molecular Sciences,2012, 13, 7038-7056.

18. Ndoye, M., Zhang, J-B., Wang, J.-H., Gong, A.-D, Qu, B., Li, H.-P., Li, S.-J, Liao, Y.-C. Nivalenol and 15-acetyldeoxynivalenol chemotypes of Fusarium graminearum clade species are prevalent on maize throughout China . Journal of Phytopathology, 2012, 160: 519-524.

19. Wang, J.-H., Zhang, J-B., Chen, F.- F., Li, H.-P., Ndoye M., Liao, Y.-C. A multiplex PCR assay for genetic chemotyping of toxigenic Fusarium graminearum and wheat grains for 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol and nivalenol mycotoxins. Journal of Food, Agriculture and Environment. 2012, 10: 505-511.

20. Liu, J.-L., Hu, Z.-Q., Xing, S., Xue, S., Li, H.-P., Zhang, J.-B., Liao, Y.-C. Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display. Molecular Biotechnology, 2012, 52: 111-122.

21. Liu, G., Han, Z., Nie, D., Yang, J., Zhao, Z. H., Zhang, J. B., Li, H.P., Liao, Y. C., Song, S., Saeger, S. D., Wu, A. B. Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Food Control, 2012, 27: 200-205.

22. Han, Z., Zhao, Z.-Y., Song, S.-Q., Liu, G., Shi, J.-X., Zhang, J.-B., Liao, Y.-C., Zhang, D.-B., Saeger, S. D., Wu, A.-B. Establishment of a model isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rat. Analytical Methods, 2012, 4, 3708–3717.

23. Wang, J.-H., Ndoye, M., Zhang, J.-B., Li, H.-P., Liao, Y.-C. Population structure and genetic diversity of the Fusarium graminearum species complex. Toxins, 2011, 3, 1020-1037.

24. 宮安東，孔憲巍，翟新可，路亞南，文淑婷，張靜柏. 枯草芽胞杆菌WY8-7的溶磷、抑菌及促生長作用. 南京農業大學學報，2019，42（4）：697-705

25. 何偉傑，劉易科，朱展望，張靜柏，高春保，廖玉才. 鐮刀菌毒素脫氧雪腐鐮刀菌烯醇脫毒菌及脫毒酶研究進展. 植物病理學報，2019，49（5）：577-589

26. 胡祖權，李和平，張靜柏，劉錦龍，廖玉才. 伏馬菌素B1特異單鍊抗體的同源建模及分子對接模拟研究. 免疫學雜志，2015，31（7）：618-622

教材與著作

1. 《普通遺傳學實驗》參編，2015，高等教育出版社

2. 《遺傳學》（第三版），參編，2015，科學出版社

3. 《植物生物技術》（第二版），參編，2012，科學出版社