學習經曆
   1981.09-1985.07 河北師範大學生物學，本科學生，獲得理學學士學位
   1988.09-1991.06 河北師範大學，碩士研究生，獲得理學碩士學位
   1998.01-2001.06 美國普渡大學園藝系博士研究生，獲得博士學位
           

工作經曆
   1985.07-1988.08 河北師範大學生物系（現生命學院）黨總支秘書
   1991.06-1992.06 河北師範大學生物系，助教
   1992.06-1995.08 河北師範大學生物系，講師，植物教研室副主任
   1995.09-1997.12 美國普渡大學生物系和園藝系，訪問學者
   2001.06-2004.02 美國夭科特煙草公司，科學家（研究員）
   2004.03-2015.08 中國科學院遺傳與發育生物學研究所和植物細胞和染色體工程國家重點實 驗室，研究員，博士生導師。農業資源研究中心副主任，中心學術委員會主任
   2015.9-至今 77779193永利官网，77779193永利官网, 教授,博士生導師
           

主要研究方向
         
 1.大豆共生固氮調控機理研究
 大豆是重要的經濟作物，是植物蛋白和油脂的主要來源。大豆可以和根瘤菌共生形成根瘤，進而把空氣中的N2轉化為植物可以利用的NH3。大豆根瘤的發育和固氮效率的高低是影響大豆産量和品質的關鍵因素。本課題組利用生理生化、分子生物學、遺傳學等綜合研究方法對大豆根瘤發育和固氮效率及其對非生物脅迫響應的分子機制進行系統性研究，重點研究大豆miRNA及靶基因影響大豆根瘤發育和固氮效率的分子調控網絡。旨在解析豆科植物共生固氮的分子機制，為分子設計培育高效固氮的高産優質豆科植物新品種提供科學依據。
         
 2.植物耐逆和可塑性發育分子機制研究
 植物對逆境響應以及抗逆的分子機制是一個重要的生物學問題，涉及到植物在逆境下的可塑性發育、基礎代謝以及植物細胞、組織和個體得能量、水分、離子、氧化還原物的穩态的調控等生物學過程。本課題組将以模式植物拟南芥和大豆為材料，采用綜合研究手段探究植物對非生物逆境尤其抗鹽堿和幹旱響應的生理和遺傳機理，重點是植物根系發育對逆境适應和調控分子網絡，逆境條件下植物防禦代謝的轉換的機制。最終目标是揭示植物抗逆的分子機理，創建耐鹽抗旱節水新作物品系。

（1） 過表達miR156b促進大豆高産和穩産，主持人，轉基因生物新品種培育重大專項，2020.01-2020.12

（2） 豆科植物根瘤菌侵染及在胞内定殖，主持人，國家自然科學基金，2020.01-2022.12

（3） 共生固氮信号轉導模塊及其豐豆科轉移機制，重大研發計劃，任務負責人，2020.1-2024.12

（4） miR172c/NNC1模塊調控大豆共生固氮和生長發育分子機理研究，主持人，國家自然科學基金重點項目，2018-2022 年

發明專利

（1）李霞，董章輝，石磊。一種與植物耐鹽性相關的miRNA gma-miRN60及其應用, 專利号：ZL201110155710.8
（2）李霞，董章輝，石磊。一種與植物耐鹽性相關的miRNA gma-miRN305及其應用，專利号：ZL201110155808.3
（3）李霞，鄒豔敏，王幼甯，陳亮，石磊，李東曉，王延偉。一種培育轉基因固氮植物的方法，專利号：ZL 201110155347.X
（4）李霞，董章輝，石磊。一種與植物耐鹽性相關的miRNA gma-miRN39及其應用，專利号：ZL201110155765.9
（5）李霞，董章輝。一種培育轉基因耐寒植物的方法，專利号：ZL201110154784.X
（6）李霞，王幼甯，陳亮，石磊，李東曉。一種與植物耐低溫相關的基因及其應用。專利号：ZL 201110155245.8
（7）李霞，王濤，王志娟。ABA和鹽相關蛋白STS1和編碼基因及應用，專利号：ZL201010590264.9
（8）李霞，趙彥坤，紀洪濤，王幼甯。 植物耐逆性相關蛋白GUI及其編碼基因和應用，專利号：ZL 201010594990.8
（9）李霞，紀洪濤，王幼甯。植物耐低溫蛋白TCF1及編碼基因和應用，專利号：ZL 201010585989.9
（10）李霞，羅焱傑，紀洪濤，王志娟。植物耐逆性相關蛋白IMBE1及其編碼基因和應用，專利号：ZL 201210090545.7
（11）李霞；王幼甯；陳亮；李科學。一種促進植物結瘤固氮的microRNA及其應用。專利申請号：20140003296.2
（12）李霞；王幼甯；陳亮；李科學；鄒豔敏；王蕊。一種RNA幹擾載體及其培育高結瘤固氮植物的應用。 專利号：ZL 201410005361.5
（13）李霞；王幼甯；鄒豔敏；陳亮。RNA幹擾載體片段、RNA幹擾載體及其應用。專利号：ZL 201410003298.1
（14）李霞；王幼甯；紀洪濤；姜瓊；趙芳；石磊；杜琳倩。一種過表達gma-miR156b培育高産株型植物的方法。專利申請号：201410478207X
         
獲得獎勵
         
2014年 獲得中國科學院遺傳發育所2014年度“優秀團隊獎”
2014年 獲得河北省省直“三八紅旗集體”榮譽稱号
2011年 “鹽脅迫下植物根系構型可塑性發育的生理和分子機理”獲得河北省自然科學獎三等獎，第一完成單位
2009年 獲得中國科學院“朱李月華優秀教師獎”
2008年 獲得“河北省女職工建功立業标兵”榮譽稱号
2004年 至今多次評為中心優秀個人和團隊獎

發表的論文及著作 （#共同第一作者，*通訊作者）

1. Wang Z#, Ren Z#, Cheng C#, Wang T#, Ji H, Zhao Y, Deng Z, Zhi L, Lu J, Wu X, Cao M, Zhao H, Liu L, Zhu J-K, Li X*. (2020). Counteraction of ABA-mediated inhibition of seed germination and seedling establishment by ABA signaling terminator in Arabidopsis. Molecular Plant DOI: https://doi.org/10.1016/j.molp.2020.06011.

2. Han Q, Ma Q, Chen Y, Tian B, Xu L, Bai Y*, Chen W*, Li X*. (2020). Variation in rhizosphere microbial communities and its association with the symbiotic efficiency of rhizobia in soybean. ISME Journal 14: 1915-1928.  

3. Yao Y, You Q, Duan G, Ren J, Chu S, Zhao J, Li X*, Zhou X*, Jiao Y*. (2020). Quantitative trait loci analysis of seed oil content and composition of wild and cultivated soybean. BMC Plant Biology 20: 51.  

4. Wang Z, Wang L, Wang Y, Li X*. (2020). The NMN module conducts nodule number orchestra. iScience 23: 100825.

5. Wang ZJ, Liu L, Cheng C, Ren Z, Xu S, Li X*. (2020). GAI functions in the plant response dehydration stress in Arabidopsis thaliana. International Journal of Molecular Sciences. 21:819.

6. Cao JS, Li GJ, Qu DJ, Li X, Wang YN*. (2020). Into the seed: auxin controls seed development and grain yield. International Journal of Molecular Sciences, 21: 1662.

7. Wang LX, Sun ZX, Su C, Wang YL, Yan QQ, Chen JH, Ott T, Li X*. (2019). A GmNINa-miR172c-NNC1 regulatory network coordinates the nodulation and autoregulation of nodulation pathways in soybean. Molecular Plant 12: 1211-1226.

8. Wang YN, Yang W, Zuo YY, Zhu L, Hastwell AH, Chen L, Tian Y, Su C, Ferguson BJ, Li X*. (2019). GmYUC2a mediates auxin biosynthesis during root development and nodulation in soybean. Journal of Experimental Botany 70: 3165-3176.

9. Ullah I, Magdy M, Wang LX, Liu MY, Li X*. (2019). Genome-wide identification and evolutionary analysis of TGA transcription factors in soybean. Scientific Reports 9: 11186.

10. Bao A, Chen H, Chen L, Chen S, Hao Q, Guo W, Qiu D, Shan Z, Yang Z, Yuan S, Zhang C, Zhang X, Liu B, Kong F, Li X, Zhou X, Tran LP, Cao D. (2019) CRISPR/Cas9-mediated targeted mutagenesis of GmSPL9 genes alters plantarchitecture in soybean. BMC Plant Biology. 8;19(1):131.

11. Sun ZX, Su C, Yun JX, Jiang Q, Wang LX, Wang YN, Cao D, Zhao F, Zhao QS, Zhang MC, Zhou B, Zhang L, Kong FJ, Liu BH, Tong YP, Li X*. (2018). Genetic improvement of the shoot architecture and yield in soybean plants via the manipulation of GmmiR156b. Plant Biotechnology Journal 17: 50-62.

12. Yan Q, Wang LX, Li X*. (2018). GmBEHL1, a BES1/BZR1 family protein, negatively regulates soybean nodulation. Scientific Reports 8: 7614.

13. Ji HT, Wang SF, Cheng CH, Li R, Wang ZJ, Jenkins GI, Kong FJ, Li X*. (2018). The RCC1 family protein SAB1 negatively regulates ABI5 through multidimensional mechanisms during post-germination in Arabidopsis. New Phytologist 222: 907-922.

14. Tang T, Yu XW, Yang H, Gao Q, Ji HT, Wang YX, Yan GB, Peng Y, Luo HF, Liu KD, Li X, Ma CZ, Kang CY, Dai C. (2018). Development and validation of an effective CRISPR/Cas9 vector for efficiently isolating positive transformants and transgene-free mutants in a wide range of plant species. Frontier in Plant Science 9: 1533.

15. Cai ZM#, Wang YN#, Zhu L, Tian YP, Chen L, Sun ZX, Ullah I, Li X*. (2017). GmTIR1/GmAFB3-based auxin perception regulated by miR393 modulates soybean nodulation, New Phytologist 215: 672-686.

16. Hussain RM, Ali M, Feng X, Li X* (2017). The essence of NAC gene family to the cultivation of drought-resistant soybean (Glycine max L. Merr.) cultivars. BMC Plant Biology 17: 55.

17. Sahito ZA, Wang L, Sun Z, Yan QQ, Zhang XK, Jiang Q, Ullah I, Tong YP, Li X*. (2017). The miR172c-NNC1 module modulates root plastic development in response to salt in soybean. BMC Plant Biology 17: 229.

18. Wang YN, Yuan JH, Yang W, Zhu L, Su C, Wang XD, Wu HY, Sun ZX, Li X*. (2017). Genome wide identification and expression profiling of ethylene receptor genes during soybean nodulation. Frontier in Plant Science 8: 859.

19. Cheng CH, Wang ZJ, Ren ZY, Zhi LY, Yao B, Su C, Liu L, Li X*. (2017). SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana. PLoS Genetics 13: e1006947.

20. Cheng CH, Wang ZJ, Yuan BJ, Li X*. (2017). RBM25 mediates abiotic responses in Plants. Frontier in Plant Science 8: 292.

21. Zheng X, Liu HP, Ji HT, Wang YN, Dong BD, Qiao YZ, Liu MY*, Li X*. (2016). The wheat GT factor TaGT2L1D negatively regulates drought tolerance and plant development. Scientific Reports 6: 27042.

22. Su C#, Liu L#, Liu HP, Ferguson BJ, Zou YM, Zhao YK, Wang T, Wang YN*, Li X*. (2016). H2O2 regulates root system architecture by modulating the polar transport and redistribution of auxin. Journal of Plant Biology 59: 260-270.

23. Sun ZX#, Wang YN#, Mou FP, Tian YP, Chen L, Zhang SL, Jiang Q, Li X*. (2016). Genome- wide small RNA analysis of soybean reveals auxin-responsive microRNAs that are differentially expressed in response to salt stress in root apex. Frontier in Plant Science 6: 1273.

24. Wang ZJ, Ji HT, Yuan BJ, Wang SF, Yao BJ, Su C, Li X*. (2015). ABA signalling is fine-tuned by antagonistic HAB1 variants. Nature Communications 6: 8138.

25. Ji HT, Wang YN, Cloix C, Li KX, Jenkins JI, Wang SF, Shang ZL, Shi Y, Yang SH, Li X*. (2015). The Arabidopsis RCC1 family protein TCF1 regulates freezing tolerance and cold acclimation through modulating lignin biosynthesis. PLoS Genetics 11: e1005471.

26. Cao D, Li Y, Wang Y, Nan H, Wang Y, Lu S, Jiang Q, Li X, Shi D, Fang C, Yuan X, Zhao X, Li X*, Liu B*, Kong F*. (2015). GmmiR156b overexpression delays flowering time in soybean. Plant Molecular Biology 89: 353-363.

27. Wang YN, Li KX, Zhang SL, Chen L, Zou YM, Liu HP, Li DX, Wang R, Tian YP, Zhao F, Ferguson BJ, Gresshoff PM, Li X*. (2015). MicroRNA167-directed regulation of the auxin response factors, GmARF8a and GmARF8b, is required for soybean (Glycine max L.) nodulation and lateral root development. Plant Physiology 168: 101-116.

28. Wang YN, Wang LX, Zou YM, Chen L, Cai ZM, Zhang SL, Zhao F, Tian YP, Jiang Q, Ferguson B, Gresshoff P, Li X*. (2014). Soybean miR172c targets the repressive AP2 transcription factor NNC1 to activate ENOD40 expression and regulate nodule initiation. Plant Cell 26: 4782-4801.

29. Ji HT, Wang SF, Li KX, Szakonyi D, Koncz C, Li X*. (2014). PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis. Plant Journal 81: 399-412.

30. Ji HT, Liu L, Li KX, Xie Q, Wang ZJ, Zhao XH, Li X*. (2014). PEG-mediated osmotic stress induces premature differentiation of the root apical meristem and outgrowth of lateral roots in wheat. Journal of Experimental Botany 65: 4863-4872.

31. Kong D, Li M, Dong Z, Ji H, Li X*. (2014). Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses. Plant Cell Report 34: 395-410.

32. Zhang SL, Wang YN, Li KX, Zou YM, Chen L, Li X*. (2014). Identification of cold-responsive miRNAs and their target genes in nitrogen-fixing nodules of soybean. International Journal of Molecular Sciences 15: 13596-13614.

33. Luo YJ, Wang ZJ, Ji HT, Fang H, Wang SF, Tian LN, Li X*. (2013). An Arabidopsis homolog of importin beta 1 is required for ABA response and drought tolerance. Plant Journal 75: 377-389.

34. Zou YM, Wang YN, Wang LX, Yang L, Wang R, Li X*. (2013). miR172b controls the transition to autotrophic development inhibited by ABA in Arabidopsis. PLoS ONE 23: e64770.

35. Li DX, Liu HL, Qiao YZ, Wang YN, Cai ZM, Dong BD, Shi CH, Liu YY, Li X*, Liu MY*. (2013). Effects of elevated CO₂ on the growth, seed yield, and water use efficiency of soybean (Glycine max (L.) Merr.) under drought stress. Agricultural Water Management 129: 105-112.

36. Dong ZH, Shi L, Wang YW, Chen L, Cai ZM, Wang YN, Jin JB, Li X*. (2013). Identification and dynamic regulation of microRNAs involved in salt stress responses in functional soybean nodules by high-throughput sequencing. International Journal of Molecular Sciences 14: 2717-2738.

37. Peng Y, Ma W, Chen L, Yang L, Li S, Zhao H, Zhao Y, Jin W, Li N, Bevan MW, Li X, Tong Y, Li Y. (2013). Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 16: 1542-1556.

38. Zhao H, Liu L, Mo H, Qian L, Cui S, Li X, Ma L*. (2013). The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE 8: e60809.

39. Ji H, Pardo JM, Batelli G, Van Oosten MJ, Bressan RA, Li X*. (2013). The salt overly sensitive (SOS) pathway: established and emerging roles. Molecular Plant 6: 275-286.

40. Zhao H, Wang X, Zhu D, Cui S, Li X, Cao Y, Ma L*. (2012). A single amino acid substitution in IIIf subfamily of basic Helix-Loop-Helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry 287: 14109-14121.

41. Hao L, Wang W, Chen C, Wang Y, Liu T, Li X, Shang Z. (2012). Extracellular ATP promotes stomatal opening of Arabidopsis thaliana through heterotrimeric G protein a subunit and reactive oxygen species. Molecular Plant 5: 852-864.

42. Zhao Y, Wang T, Zhang W, Li X*. (2011). SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134.

43. Cao M, Li X*. (2010). Die for living better: Plants modify root system architecture through inducing PCD in root meristem under severe water stress. Plant Signaling & Behavior 5: 1-2.

44. Orsini F, D'Urzo MP, Inan G, Serra S, Oh DH, Mickelbart MV, Consiglio F, Li X, Jeong JC, Yun DJ, Bohnert HJ, Bressan RA, Maggio A. (2010). A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana. Journal of Experimental Botany 61: 3787-3798.

45. Zhao Y, Wang T, Zhang W, Li X*. (2010). SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134.

46. Duan Y, Zhang W, Li B, Wang Y, Li K, Sodmergen, Han C, Li X*. (2010). An ER response pathway mediates programmed cell death of root tip induced by water stress in Arabidopsis. New Phytologist 186: 681-695.

47. Xu J, Yin H, Liu X, Li X*. (2010). Salt affects plant Cd-stress responses by modulating growth and Cd accumulation. Planta 231: 449-459.

48. Xie Q, Yan X, Liao X, Li X*. (2009). The arsenic hyperaccumulator fern Pteris vittata L. Environmental Science & Technology 43: 8488-8495.

49. Xu J, Yin H, Li X*. (2009). Protective effects of proline against cadmium toxicity in micropropagated hyperaccumulator, Solanum nigrum L. Plant Cell Reports 28: 325-333.

50. Wang Z, Li X*. (2009). IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants. Plant Signaling & Behavior 4: 1-3.

51. Wang YN, Li KX, Li X*. (2009). Auxin redistribution modulates plastic development of root system architecture under salt stress in Arabidopsis thaliana. Journal of Plant Physiology 166: 1637-1645.

52. Wang YW, Li P, Cao XF, Wang XJ, Zhang AM, Li X*. (2009). Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochemical and Biophysical Research Communications 378: 799-803.

53. Quist T, Sokolchik I, Shi H, Joly R, Bressan R, Maggio A, Narsimhan M, Li X*. (2009). HOS3, an ELO-Like gene, inhibits effects of ABA and implicates a S-1-P/Ceramide control system for abiotic stress responses in Arabidopsis thaliana. Molecular Plant 2: 138-151.

54. Xu J, Yin H, Wang W, Mi Q, Liao X, Li X*. (2009). Identification of Cd-responsive genes of solanum nigrum seedlings through differential display. Plant Molecular Biology Reporter 27: 563-569.

55. Wang X, Gao Z, Wang Y, Bressan RA, Weller SC, Li X*. (2009). Highly efficient in vitro adventitious shoot regeneration of peppermint (Mentha x piperita L.) using internodal explants. In Vitro Cellular & Developmental Biology- Plant 45: 435-440.

56. Manabe Y, Bressan R, Wang T, Li F, Koiwa H, Sokolchik I, Li X*, Maggio A*. (2008). The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na⁺ stress. Plant Physiology 146: 612-622.

57. Sun FF, Zhang WS, Hu HZ, Li B, Wang YN, Zhao YK, Liu MY, Li X*. (2008). Salt modulates gravity signaling pathway to regulate growth direction of primary roots in Arabidopsis thaliana. Plant Physiology 146:178-188.

58. Wang YN, Zhang WS, Li KX, Sun FF, Han CY, Wang YK, Li X*. (2008). Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. Journal of Plant Research 121: 87-98.

59. Wang YN, Li X*. (2008) Salt stress-induced cell reprogramming cell fate switch and adaptive plasticity during root hair development in Arabidopsis. Plant Signaling & Behavior 3: 436 -438.

60. Li X*, Zhang WS. (2008). Salt-avoidance tropism in Arabidopsis. Plant Signaling & Behavior 3: 351-353.

61. Liu C, Wang T, Zhang WS, Li X*. (2008). Computational identification and analysis of immune-associated nucleotide gene family in Arabidopsis thaliana. Journal of Plant Physiology 165: 777-787.

62. Wang YN, Wang T, Li KX, Li X*. (2008). Genetic analysis of involvement of ETR1 in plant response to salt and osmotic stress. Plant Growth Regulation 54: 261-269.

63. Li KX#, Wang YN#, Han CY, Zhang WU, Jia H, Li X*. (2007). GA signaling and CO/FT regulatory module mediate salt-induced late flowering in Arabidopsis thaliana. Plant Growth Regulation 53: 195-206.

64. Inan G, Goto F, Jin J, A Rosado, Koiwa H, Shi H, Hasegawa PM, Bressan RA, Maggio A, Li X*. (2007). Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant Molecular Biology 65: 295-309.

65. Wang YN, Liu C, Li KX, Sun FF, Hu HZ, Li X*. (2007). Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Plant Molecular Biology 64: 633-644.

66. Zhang W, Li X, Liu JB. (2007) Genetic variation of Bmy1 alleles in barley (Hordeum vulgare L.) investigated by CAPS analysis. Theoretical Applied Genetics 114: 1039-1050.

出版書的章節

1. Liu L, Guo GY, Wang ZJ, Ji HT, Mou FP, Li X*. (2014) Auxin in plant growth and stress responses. In: Lam-Son Phan Tran and Sikander Pal (eds). Phytohormones: A window to metabolism, signaling and biotechnological application. Springer Science, New York, USA, pp1-35.

2. Zhao YK, Wang T, Zhang WS, Li X*. (2010) The role of auxin in plastic development of plant root system architecture in response to abiotic stimuli. Plant Nutrition and Abiotic Stress Tolerance. Global Science Books. Isleworth, UK, pp19-32.

本實驗室秉承“快樂科研”理念，常年招收博士後、客座研究生及科研助理。歡迎對大豆共生固氮分子機制及植物抗逆機制研究感興趣的優秀科研青年申請！歡迎各高校和研究單位同學報考本實驗室碩士和博士研究生！

We are looking for highly talented and motivated candidates (postdoctoral fellows, graduate students (MSc and Ph. D.) and honors undergraduate students) to join our team, preferably with a strong background in plant molecular, cell, developmental biology and microbiology.